PATHOGENETIC SUBSTANTIATION OF APPLICATION OF NOOKLERIN (DEANOL ATSEGLUMAT) IN THE RESTORATION OF THE METABOLIC CAPACITY OF THE BLOOD

Mikulyak Nadezhda Ivanovna, Candidate of biological sciences, associate professor, head of human physiology sub-department, Medical institute, Penza State University, normphys@mail.ru
Kinzirskaya Yuliya Alexandrovna, Candidate of medical sciences, assistant, sub-department of clinical pharmacology, Russian State Medical University, normphys@mail.ru
Mikulyak Artur Ivanovich, Student, Medical institute, Penza State University, mixuss@rambler.ru

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Experimentally studied the influence of Deanol aceglumate (Nooclerinum) on functional activity of hepatocytes enzyme’s exchange, lipid peroxidation of animals during chemotherapy by cyclophosphanum. It is shown that studied medicine eliminates the lipid peroxidation induced by cyclophosphanum, reduces MDA, in-creases the activity of antioxidant enzymes in serum and in tissues the last predeter-mine the feasibility of using of Denol aceglumate (Nooclerinum) in the complex therapy with the activation of process of lipid peroxidation.

lipid peroxidation, Deanol aceglumate, cyclophosphanum, MDA, anti-oxidative enzymes.